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Clomiphene – Drug Information

Category X :

Animal and/or human studies have demonstrated fetal injury and potential risks outweigh the benefits of the drug in pregnancy. These drugs are found to be harmful when taken during pregnancy, and should not be used.

Dosage & When it is to be taken (Indications):

Oral: 50 mg/day for 5 days starting on the 5th day of menstrual cycle or at any time if there is absence of a menstrual period. It may be increased to 100 mg/day for the 2nd course as early as 30 days after previous therapy if needed. Total max: 6 treatment cycles.

How it should be taken :

It comes as a tablet to take by mouth. It is usually taken once a day.

Warnings and Precautions :

It may cause, uterine fibroids, blurred vision, dizziness. Do not drive a car or operate machinery, especially in poor lighting, until you know how this medication affects you.
Polycystic ovaries, evaluate presence of ovarian cyst before each cycle treatment.

Side Effects :

Heart – Vasomotor flushes.

Central Nervous System – Headache, dizziness, lightheadedness.

Eye – Visual symptoms, blurring spots or flashes, double vision, photophobia.

Gastrointestinal – Abdominal pain/discomfort, distension, bloating, nausea, vomiting.
♦
Genitourinary – Multiple pregnancies, abnormal ovarian enlargement, abnormal uterine bleeding; ovarian cyst formation, ovarian hyperstimulation syndrome. risk of ovarian tumor.

Liver – Liver function tests abnormalities.
♦
Miscellaneous – Breast tenderness and hives.

Other Precautions :

Pregnancy with more than 1 fetus (eg, twins) is possible while taking this medication.Consult with your doctor about multiple pregnancy.

Storage Conditions :

Oral: Store at 15-30�C.Store it in room temperature and in airtight container. ♦ Safety Labeling Changes Approved By FDA

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.

Hi, my doc prescribed me siphene-100 mg tablets for 5 days starting from 3rd day of my periods. but i missed 3rd and 4th day and started taking on 5th day only and just 3 tablets for 3 days -. please let me know if it is ok, and can we have sex the very next day after having tablet. please help. my cycle is 24 days.
anto123 Thursday, July 30, 2015

can we have sex while taking clomiphene tablets ip clome 50
Ravelin Thursday, January 29, 2015

Hi, I’m on Clomid 25 mg for 11 days [started on 3th day of period]. Now, there are 3 eggs with same size of 11 mm. So my doctor prescribed more 4 days with same dose. Can they ovulate while this period (extended 4 days)? Or it can ovulate after hcG injection?
Nonavitamins Thursday, September 5, 2013

Hi, my doc prescribed me siphene-100 mg tablets for 5 days starting from 3rd day of my periods. but i missed 3rd & 4th day and started taking on 5th day only and just 3 tablets for 3 days -. please let me know if it is ok, & can we have sex the very next day after having tablet. please help. my cycle is 24 days.
Sheetu Friday, February 22, 2013

Hi there i have the Rejun 50 tablet but I don’t get my period every month the last period i had was in November 2012 and now it’s January 24,2013 so what i would like to know is that can i take it without having my period or should i wait till i get my period.I married for 5 years now and i would love to give my Hubby a child and yes i have a son that’s 12 years old now it’s time to add more to the family, please help me someone need help .
elouaze Thursday, January 24, 2013

Clomid is an non-steroid anti-estrogen. Mechanism of its action consists in a specific binding with receptor for estrogen in ovary and hypophis. In patients with low estrogen levels in organism it causes estrogen effect and in ones with high estrogen levels it causes anti-estrogen effect. Its small doses increase secretion of gonadotropins (prolactin, Follicle stimulating hormone, FSH and interstitial cell-stimulating hormone), stimulates ovulation; in large doses slows secretion of gonadotropins. Clomid stimulates ovulation and prepares the body for pregnancy. This medication may be used for male patients with infertility caused by low production of sperm.

Dosage and direction

Clomid is administered to stimulate ovulation. It is recommended to start with 50 mg 1 time a day at bedtime, starting from 5th day of the menstrual cycle during 5 days (in the absence of the cycle – at any time). In case of no effect (ovulation does not occur within 30 days) increase the dose to 150 mg / day or lengthen the course to 10 days. Take exactly as prescribed, do not take the medication in larger quantities.

Precautions

Before taking Clomid notify your doctor if you have ever had any allergic reaction to clomiphene, liver diseases, mental depression, thrombophlebitis. This drug may cause vision problems, dizziness, or lightheadedness, be especially attentive if you need driving or operating machinery which requires high concentration of attention.

Hypersensitivity, liver or kidney failure, metrorrhagia of unknown etiology, ovarian cysts, neoplasms of genital organs, tumor or hypofunction of the hypophysis, endometriosis, ovarian failure together with hyperprolactinaemia, pregnancy.

Possible side effect

Together with allergy symptoms such as swelling of lips, tongue, or face or hives in some patients may appear the following conditions: ovarian enlargement presenting as abdominal or pelvic pain, flushing, nausea, vomiting, or diarrhea, blurred vision, headache, abnormal uterine bleeding.

Drug interaction

Inform your doctor and laboratory operators about all medications and herbal products you are taking if you are treated with Clomid.

Missed dose

If you missed a dose take it as soon as you remember, but not if it is almost time of the next intake according to your schedule. If so skip the missed dose. Do not try to make up a missed dose by taking an extra one.

Overdose
If you suspect that you took too much of the medication seek for immediate medical attention.

Storage

Store Clomid in a dry place away from sunlight at room temperature between 15-30 C (59-86 F).

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. The specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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